Calorie restriction reduces rDNA recombination independently of rDNA silencing
نویسندگان
چکیده
منابع مشابه
Calorie restriction reduces rDNA recombination independently of rDNA silencing
Calorie restriction (CR) extends lifespan in yeast, worms, flies and mammals, suggesting that it acts via a conserved mechanism. In yeast, activation of the NAD-dependent histone deacetylase, Sir2, by CR is thought to increase silencing at the ribosomal DNA, thereby reducing the recombination-induced generation of extrachromosomal rDNA circles, hence increasing replicative lifespan. Although ac...
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ژورنال
عنوان ژورنال: Aging Cell
سال: 2009
ISSN: 1474-9718,1474-9726
DOI: 10.1111/j.1474-9726.2009.00514.x